安徽中医学院学报2011，Vol.30Issue(2)：52-54,3.DOI:10.3969/j.issn.1000-2219.2011.02.020
化痰通瘀解毒方对S180小鼠移植瘤微血管密度及血管内皮生长因子表达的影响
Effects of Huatan Tongyu Jiedu Recipe on Expression of Microvessel Density and Vascular Endothelial Growth Factor in Mice Bearing S180 Transplanted Tumor
摘要
Abstract
Objective To explore the mechanism of Huatan Tongyu Jiedu (HTJ) Recipe, a traditional Chi nese prescription for removing phlegm, activating blood circulation and detoxicating, in inhibiting the an giogenesis of tumor microvessels. Methods The model of S180 transplanted tumor was induced in mice. An immunohistochemical method was employed to observe the effects of HTJ Recipes on the expression of microvessel density (MVD) and vascular endothelial growth factor (VEGF). Results The expression lev els of MVD and VEGF were significantly decreased in low (20.0 g/kg), middle (40.0 g/kg), and high (60.0 g/kg) dose HTJ Recipes treated groups in comparison with those of the model group (P＜0.05, or P＜0.01). Conclusion HTJ Recipes can inhibit the angiogenesis of tumor by inhibiting the expression of VEGF.关键词
化痰通瘀解毒方/S180/移植瘤/微血管密度/血管内皮生长因子分类
医药卫生引用本文复制引用
黄金玲,王桐生,王训翠,王靓,蔡横,桑方方,刘先华..化痰通瘀解毒方对S180小鼠移植瘤微血管密度及血管内皮生长因子表达的影响 [J].安徽中医学院学报,2011,30(2):52-54,3.基金项目
安徽省高等学校自然科学研究项目(2006KJ336B) （2006KJ336B）
