安徽中医学院学报2011，Vol.30Issue(2)：57-60,4.DOI:10.3969/j.issn.1000-2219.2011.02.022
栀子苷在正常大鼠体内的药物代谢动力学和组织分布
Pharmacokinetics and Tissue Distribution of Jasminoidin in Normal Rats
摘要
Abstract
Objective To study pharmacokinetics of Jasminoidin (JA) in rat plasma and distribution of JA in the liver, the spleen, the kidney and the brain of rats. Methods Phenomenex C18 column (4. 6 mm×250 mm,5 μm) was used. The mobile phase was acetonitrile-0.01％ phosphoric acid (20: 80) ;the flow rate was 0. 8 ml/min;the column temperature was at 30℃ ;and the ultraviolet detection wave was set at 238nm. High Performance Liquid Chromatography was used to study the concentration of JA and tissue distribution of JA in the brain, the liver, the spleen, and the kidney after intragastric administration of JA in normal rats at different time points. The pharmacokinetics parameters of JA were calculated by DAS 2.0 Program. Results The concentration-time curve of JA was fitted to a two-compartment model with a weight of 1. The concentration of JA was the highest in the liver, and it decreased in the liver, the spleen and the brain, gradually. Conclusion This method can be used for the study on pharmacokinetics and tissue distribution of JA because of its simplicity, accuracy and stability.关键词
栀子苷/高效液相色谱法/药物代谢动力学/组织分布分类
医药卫生引用本文复制引用
吴欢,吴虹,袁美燕,沈晨..栀子苷在正常大鼠体内的药物代谢动力学和组织分布 [J].安徽中医学院学报,2011,30(2):57-60,4.基金项目
国家自然科学基金(81073122) （81073122）
安徽省高等学校自然科学研究重点项目(KJ2009A045Z) （KJ2009A045Z）
年安徽中医学院自然科学基金项目(2010zr010B) （2010zr010B）
