北京生物医学工程2011，Vol.30Issue(2)：141-145,5.DOI:10.3969/j.issn.1002-3208.2011.02.07.
不同电极电刺激对有髓神经传导阻断影响的仿真研究
Simulation of Myelinated Nerve Conduction Block Induced by Electrical Stimulus of Monopolar and Bipolar Electrodes
摘要
Abstract
To compare the thresholds and the degrees of axonal injury caused by the impulse stimulations of monopolar and bipolar electrodes in simulation study of nerve conduction block. This study aimed to find an optimal stimulus pattern for the animal experiment of restoring the normal function of lower urinary tract after spinal cord injury through electrical stimulation. We used the myelinated nerve fiber with limited length as the research object, and the Frankenhaeuser-Huxley ( F - H) model for mammal' s marrow nerve fiber as the basic system. We simulated the symmetry biphasic pulses and intermittent biphasic pulses to compare the block threshold and ionic current intensity generated by monopolar and bipolar electrodes. The simulating results indicated that the conduction block threshold induced by bipolar electrode is higher than that of monopolar electrode, and monopolar electrode caused greater damage to the axon when the other situations were same.关键词
双电极/单电极/传导阻断/阈值/神经损伤分类
医药卫生引用本文复制引用
孙晨,张旭,任朝晖,董谦,崔南..不同电极电刺激对有髓神经传导阻断影响的仿真研究[J].北京生物医学工程,2011,30(2):141-145,5.基金项目
北京市教委科技发展计划(KM200710025008)资助 （KM200710025008）
