重庆医学2011，Vol.40Issue(10)：949-951,953,封2,5.DOI:10.3969/j.issn.1671-8348.2011.10.006
大鼠肝纤维化中超声造影的实验研究
Experimental study of contrast enhanced ultrasound in rats with liver fibrosis
摘要
Abstract
Objective To explore the value of contrast enhanced ultrasound in early diagnosis of liver fibrosis in rats. Methods Sixty SD rats were divided into two groups randomly,8 as control group,52 for liver fibrosis mode. 50％ CCl4 was percutaneously injected twice a week for 12 weeks at 0. 3ml/100g With the first administration at 0. 5ml/100g. At the 3 th,6 th,9 th, and 12 th week,10 rats from liver fibrosis group and 2 rats from control group were selected for CFUS, recording HAAT, PVAT, HVAT, and calculating HAHVTT( HVATHAAT). In CnTI program obtained the timeintensity curve of liver parenchyma and recorded the time to peak,peak intensity,ascending slope,descent slope. All rats were grouped according to pathological liver fibrosis stage. Results With the progress of liver fibrosis, HVAT. HA-HVTT was shorter in S3 and S4 stage than in control group, S1and S2 stage. The parenchyma time-intensity curve analysis showed that peak intensity and descent slope was lower in S3 and S4 stage than in control group,S1 and S2 stage. Conclusion CFUS can be used to observe the developing process of the hepatic artery, portal vein,hepatic vein and can demonstrate hemodynamic trend in different liver fibrosis stage. It also provides a new possibilitv for non invasive diagnosis of liver cirrhosis.关键词
肝硬化/超声造影/动物实验引用本文复制引用
李宏波,张炽敏,庄华..大鼠肝纤维化中超声造影的实验研究[J].重庆医学,2011,40(10):949-951,953,封2,5.基金项目
南京市卫生局青年科技人才启动基金资助项目(QYK09153). （QYK09153）
