中国实用儿科杂志2011，Vol.26Issue(3)：187-189,3.
甲型H1N1流感患儿细胞免疫特点分析
Analysis of the cellular immunity features in children with noval H1N1 influenza
摘要
Abstract
Objective To approach variance of the cellular immunological function of the confirmed cases of those children with H1N1 influenza. Methods A total of 86 confirmed cases with the novel H 1N 1 influenza A virus infection, including critical group and severe group, were diagnosed according to the criteria of the Center for Disesse Control and Prevention of China from October 2009 to January 2010 in our department. Their cellular immunity function were tested with flow cytometry, and the lymphocyte subsets of 23 children in the Department of Surgery were set as the control group. Results Compared with group, percentage of CD3+, CD3+CD4+, CD3+CD8+ subsets decreased obviously in critical group and severe group, with no significant variance between them; percentage of CD19+CD23+, CD3-CD19+ subsets were presented as control group ＞ severe group ＞ critical group, with obvious statistical variance with each other; percentage of CD3-CD16+CD56+ decreased remarkably in group severe group; however, no statistical result was found with the ratio of CD4 +/CD8+ among all the groups. Conclusion In Suzhou, children with the pandemic (H1N1) 2009 virus infection have obvious disorder in their cellular immunity function. T lymphocytes are extensively depressed early in the course; B lymphoeytes are involved in the virus clearance; decrease of percentage of NK cells has correlation with those critical cases.关键词
H1N1亚型/流感病毒A型/感染/儿童/细胞免疫分类
医药卫生引用本文复制引用
储矗,季伟,贾颖,刘静,周卫芳,陈正荣..甲型H1N1流感患儿细胞免疫特点分析[J].中国实用儿科杂志,2011,26(3):187-189,3.基金项目
苏州社会发展科技计划项目[NO.SS0702] （）
