重庆医学2011，Vol.40Issue(11)：1055-1057,1060,封3,5.DOI:10.3969/j.issn.1671-8348.2011.11.006
EphA2、CD34、D2-40在卵巢上皮性肿瘤中的表达及其与临床病理的关系
The expressions of EphA2, CD34 and D2-40 in ovarian epithelial neoplasms and their relationships with clinicopathology
徐敏 1李洁华 1许丹 1邵伟伟 2张玉泉2
作者信息
- 1. 江苏省南通大学第四附属医院妇产科,224001
- 2. 江苏省南通大学附属医学妇产科,226001
- 折叠
摘要
Abstract
Objective To examine the expressions of EphA2 , CD34 and D2-40 in ovarian epithelial neoplasms, and investigatetheir relationships with clinicalpathologh.Methods SP immunohistochemical staining was used to examine the expressions of E-phA2 , CD34 and D2-40 in 10 normal ovarian specimens , 48 benigh ovarian specimens,47 boundary ovarian specimens and 205 malig-nant ovarian specimens.Results (1) The expressions of EphA2 ,CD34 and D2-40 in normal ovarian tissues were higher than in o-varian epithelial neoplasms(P＜0.01).(2) The expressions of CD34MVD,D2-40-LMVD in the maglignant ovarian epithelial neo-plasms were positively related to clinical stage, differential and lymph node metastasis (P＜0.05).But no statistically difference wasfound between them with the patients＇ age( P＞ 0.05 ) .( 3) A statistically difference of MVD and LMVD were found between the differentgrade expressions of EphA2 in malignant Ovarian(P＜0.01).And the expressions of EphA2 were positively correlated with CD34-MVDand D2-40-LMVD(P＜0.01).The expressions of CD34-MVD and D2-40-LMVD were positively correlated with each other in malignantneoplasms(P＜0.01).Conclusion EphA2 overexpression on the one hand could promote the proliferation of tumor cells.关键词
卵巢肿瘤/病理学,临床/EphA2/CD34/D2-40引用本文复制引用
徐敏,李洁华,许丹,邵伟伟,张玉泉..EphA2、CD34、D2-40在卵巢上皮性肿瘤中的表达及其与临床病理的关系[J].重庆医学,2011,40(11):1055-1057,1060,封3,5.
