热消融联合消融灶周边注射CpG ODN抑制小鼠肝癌生长的研究OACSTPCD
Research of of Thermal Ablation Combined with CpG ODN on the Treatment of Live Cancer in Mice
目的 探讨热消融联合消融灶周边注射CpG ODN治疗对小鼠肝癌的影响及继发免疫效应的抗肿瘤效果.方法 建立Hepa1-6小鼠皮下肝癌动物模型32只,随机分为热消融治疗组、热消融联合CpG ODN治疗组、CpG ODN治疗组和对照组,每组8只.每组各6只接种肿瘤细胞后第7天、第14天给予治疗,测量小鼠肿瘤体积,观察荷瘤小鼠存活率及消融灶内淋巴细胞和HSP70变化,另8只第7天给予治疗,30 d后对侧接种等量肿瘤细胞,1个月后处死,观察小鼠生存状况及…查看全部>>
Objective To investigate the therapeutic effect of thermal ablation combined with CpG ODN on the treatment of liver cancer in mice. Methods After the subcutaneous tumor model( Hepa1 -6 )was established in mice,32 mice were randomly divided int0 4 groups( n =8 ). Except the control group,tumor cells were injected into 6 mice in each group at the 7th day and the 14th day. 30 days after the first therapy, their tumor volumes, survival rate and the growth sta…查看全部>>
刘星;向邦德;赵荫农
广西医科大学附属肿瘤医院肝胆外科,南宁市,530021广西医科大学附属肿瘤医院肝胆外科,南宁市,530021广西医科大学附属肿瘤医院肝胆外科,南宁市,530021
医药卫生
肝癌免疫治疗CpG ODN热消融
《广西医学》 2011 (2)
143-146,4
广西科学研究与技术开发计划项目(桂科攻0815007-2-6)广西医药卫生科学研究基金(桂科重200702)广西医科大学博士启动基金(项目308021)
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