广东医学2011，Vol.32Issue(1)：61-63,3.
原发性高血压合并糖耐量减低患者脉搏波传导速度与内皮功能的变化
Changes in pulse wave velocity and endothelium function in essential hypertension patients with impaired glucose tolerance.
摘要
Abstract
Objective To investigate the changes in pulse wave velocity ( PWV ) in essential hypertension ( EH ) patients with impaired glucose tolerance ( IGT ), and to analyze the correlation of PWV with nitric oxide ( NO ) and endothelin ( ET ). Methods The levels of baPWV, NO and ET in serum were measured in normal control group ( Group A,n= 42 ), simple hypertension group ( Group B, n= 40 ) and hypertension combined with IGT group ( Group C, n= 45 ).Results Compared with those in Group A, NO level in serum was significantly reduced, with increased baPWV and ET in Group B and C ( P ＜ 0. 05 ). Compared with those in Group B, NO level in serum was significantly reduced, with increased baPWV and ET in Group C ( P ＜ 0. 05 ). Significantly negative and positive correlations were revealed between baPWV and NO, and between baPWV and ET, respectively, in Group C according to linear correlation analysis ( both P ＜ 0. 05 ). Meanwhile, baPWV was significantly correlated with age, pulse pressure and 2 - hour postprandial blood glucose ( all P ＜ 0. 05 ). Conclusion Vascular endothelium function is obviously impaired in EH patients. The endothelial injury and stiffness of arteries are exacerbaeted by IGT in these patients.关键词
原发性高血压/糖耐量减低/脉搏波传导速度/内皮功能Key words
essential hypertension/ impaired glucose tolerance/ pulse wave velocity/ endothelium function引用本文复制引用
韩文杰,刘恒亮,康秀芬..原发性高血压合并糖耐量减低患者脉搏波传导速度与内皮功能的变化[J].广东医学,2011,32(1):61-63,3.基金项目
郑州市科技创新领军人才项目(编号:096SYJH33114) （编号:096SYJH33114）
