临床神经外科杂志2011，Vol.8Issue(1)：10-12,3.DOI:10.3969/j.issn.1672-7770.2011.01.004
VM26联合MeCCNU在人脑低级别胶质瘤治疗中应用的初步探讨
Primary exploration of the efficiency of VM26 combined with MeCCNU therapy for the low-grade gliomas
曹广辉 1谭卫国 1冯鸣 1申昊 1王君祥 1黄煜伦 1周幽心1
作者信息
- 1. 215000,苏州大学附属第一医院神经外科
- 折叠
摘要
Abstract
Objective To explore the efficiency of VM26 combined with MeCCNU therapy for the low-grade gliomas of MCMT-positive after tumor resection and radiotherapy. Methods The clinical data of 22 patients with MCMT-positive who underwent total removal of tumors with enhanced MRI imaging showing no residual tumors from Jan 2005 to Oct 2008 in our department were analyzed retrospectively. Of 22 patients . 10 were diffuse astrocytomas; 3 were oligodendrogliomas;5 were are mixed oligo-astrocytomas and 4 ependymomas. These patients received three-dimensional conformal radiotherapy 2 -4 weeks after surgery with radiation and exposure dose being ( 50～ 55 ) Gy( 6 ～ 7 )weeks. 2 weeks after the end of radiotherapy , these patients underwent VM26 comhined with MeCCNU therapy ( VM26 : 50mg/m2/day , intravenous dripping for 3 days , repeated after 8 weeks for 3 cycles.MeCCNU: 50mg/m2/day, taken orally for 3 days, repeated after 8 weeks for 4 cycles) with MRI scanning regularly. Results Of 22 MCMT-positive grade Ⅱ gliomas,6 cases were positive for both TopoⅡα and Pgp,10 and 2 were only positive for TopoⅡα and Pgp, respectively; and 4 were negative for both TopoⅡα and Pgp. The following up from 2 t0 5 years showed tumors recurred in 6 cases with average time of recurrence being 16. 6 months ,CT or MRI imaging showed no tumor recurrence in 13 ,3 underwent the second surgery due to MRI imaging showing possible tumor recurrence 2 vears after prior surgery. Pathological examination reported suspected recurring tumor was necrotic tissue. In these 22 patients , one vear survival rate of one vear was 100％ and two vears was 88.9％ . Conclusions VM26 combined with MeCCNU chemotherapy is able to efficaciously inhibit the growth of gliomas ,with little side-effects.safety. It's an therapeutic method for patients with low-grade MGMT-positive gliomas aftert tumor resection and radiotherapy.关键词
胶质瘤/化学治疗分类
医药卫生引用本文复制引用
曹广辉,谭卫国,冯鸣,申昊,王君祥,黄煜伦,周幽心..VM26联合MeCCNU在人脑低级别胶质瘤治疗中应用的初步探讨[J].临床神经外科杂志,2011,8(1):10-12,3.
