临床神经外科杂志2011，Vol.8Issue(1)：1-3,3.DOI:10.3969/j.issn.1672-7770.2011.01.001
胶质瘤组织芯片cathepsin D的表达和临床意义
Study of cathepsin D expression for gliomas with tissue microarray
虞剑 1张海石 1陈宏 2黄峰平1
作者信息
- 1. 200040,复旦大学附属华山医院神经外科
- 2. 200040,复旦大学附属华山医院神经病理科
- 折叠
摘要
Abstract
Objective To analyze the expression of cathepsin D in gliomas and its clinical meaning with high-throughput tissue microarray/ tissue chip. Methods The expression of cathepsin D in the paraffin samples of 300 patients with gliomas were examined by using immunohistochemistry on tissue chip. Results In the astrocytoma specimens, the positive expression of cathepsin D is significantly different between pathological grade Ⅰ - Ⅱ ( positive ratio56. 84％ ) and Ⅲ -Ⅳ positive rati0 81. 89％ ) . as well as the positive intensity. Positive ratio ＆ positive intensity are both significantly different between high grade astrocytomas ( grade Ⅲ -Ⅳ ) and normal tissue ( positive ratio 31. 5％ ) . In the ependymocytoma specimens, the positive expression of cathepsin D is not significantly different between pathological grade Ⅱ and Ⅱ .but was significantly difference between tuomr and normal tissue. In the oligodendroglioma specimens , the positive expression of cathepsin D is significantly different between pathological grade Ⅱ ( positive rati9.66. 66％ ) and Ⅲ ( positive ratio 86. 95) .as well as the positive intensity. Positive ratio ＆ positive intensity are both significantly different between oligodendrogliomas tumor tissue and that of normal( positive ratio 31. 5％ ) ( P ＜0. 05) . Conclusions The expression of cathepsin D was positively correlated with the pathological grade of astrocytomas and oligodendrogliomas. These results suggest that cathepsin D could be a potential molecular marker for high grade astrocytomas and oligodendrogliomas.关键词
胶质瘤/组织芯片/组织蛋白酶D分类
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虞剑,张海石,陈宏,黄峰平..胶质瘤组织芯片cathepsin D的表达和临床意义[J].临床神经外科杂志,2011,8(1):1-3,3.
