临床与实验病理学杂志2011，Vol.27Issue(2)：146-149,4.
甲状腺乳头状癌组织中E-cadherin、β-catenin 和cyclinD1蛋白表达及意义
Expression of E-cadherin,β-catenin and cyclinD1 proteins in papillary thyroid carcinoma and their clinical significance
刘泽兵 1王丽 1叶宣光 1于秀杰 2张友元1
作者信息
- 1. 复旦大学附属金山医院病理科,上海,200540
- 2. 天津医科大学内分泌研究所卫生部激素与发育重点实验室,天津,300070
- 折叠
摘要
Abstract
Purpose To investigate the expression of E-cadherin, β-catenin, and cyclinD1 proteins in papillary thyroid carcinoma( PTC )and their clinical significance. Methods 36 cases of PTC and 27 cases of normal thyroid tissue around thyroid adenoma were selected.Expression of E-cadherin, β-catenin, cyclinD1 proteins was detected hy immunohistochemistry. Results The percentages of cases positive for various markers were 30. 56 ％( P＜ 0. 05 )for E-cadherin , 80. 56％ ( P ＜ 0. 01 )for β-catenin , and 72. 220％ ( P ＜ 0. 01 )for cy clinDI , respectively. The aberrant expression rates of E-cadherin, β-catenin, and cyclinDl in PTC were closely related to lymph node metastasis. Moreover.there was a negative correlation between the decreased expression of E-cadherin and the high expression of cy-clinDI( P ＜ 0. 05 ) , and a positive correlation between the aberrant expression ofβ-catenin and the high expression of cyclinD1( P ＜0. 05 ). Conclusions Decreased expression of E-cadherin and aberrant expression of β-catenin could induce activation or facilitation of cyclinDI overexpression . and affect the pathogenesis and progression of PTC.关键词
甲状腺肿瘤/乳头状癌/E-cadherin/β-catenin/cyclinD1分类
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刘泽兵,王丽,叶宣光,于秀杰,张友元..甲状腺乳头状癌组织中E-cadherin、β-catenin 和cyclinD1蛋白表达及意义[J].临床与实验病理学杂志,2011,27(2):146-149,4.
