临床与实验病理学杂志2011，Vol.27Issue(2)：138-141,4.
大肠癌伴血吸虫病组织中AKT1、survivin的表达及意义
Expression of AKT1,survivin and their clinical significance in colorectal cancer with schistosomiasis
徐松 1冯一中 2李海1
作者信息
- 1. 苏州大学医学院病理生理学与病理学系,苏州,215004
- 2. 江苏省昆山市第一人民医院,昆山,215300
- 折叠
摘要
Abstract
Purpose To explore the expression of AKTl , survivin in colorectal adenocarcinoma with schistosomiasis and their clinical significance. Methods Immunohistochemical SP staining method was adopted to detect the expression of AKTI and survivin in 75 cases of colorectal adenocarcinoma with or without schistosomiasis.and in 40 cases of normal colorectal mucosa with or without schistosomiasis. Results The difference of positive expression of AKT1 and survivin was significant between colorectal adenocarcinoma and normal colorectal mucosa( P ＜ 0. 01 .P ＜ 0. 01 ),the positive expression of survivin appeared to relate to histological differentiation and survival time( P＜ 0. 05 ). There was a significant positive correlation hetween AKT1 and survivin( P ＜ 0. 01 ). The difference of positive expression of AKT1 and survivin was not significant hetween colorectal adenocarcinoma with schistosomiasis and without schistosomiasis ( P＞0. 05 ). Conclusion There is highly positive expression of AKT1 and survivin,which suggests that these factors are concerned with the development and progression of colorectal adenocarcinoma. The expression of AKT1 and survivin between colorectal adenocarcinoma with schistosomiasis and without schistosomiasis has no obvious variation,which proves that schistosomiasis has no evident effect on the progression of colorectal adenocarcinoma.关键词
大肠肿瘤/AKT1/survivin/免疫组织化学/日本血吸虫病分类
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徐松,冯一中,李海..大肠癌伴血吸虫病组织中AKT1、survivin的表达及意义[J].临床与实验病理学杂志,2011,27(2):138-141,4.
