临床与实验病理学杂志2011，Vol.27Issue(2)：134-137,4.
胃窦黏膜肠上皮化生类型与程度的关系及其临床意义
Correlation between type and degree of intestinal metaplasia in antrum of stomach and its clinical significance
刘杰英 1韩艳春 1杨东霞 1刘鲁英1
作者信息
- 1. 滨州医学院病理学教研室,滨州,256603
- 折叠
摘要
Abstract
Purpose To explore the clinical significance of detecting the type and degree of intestinal metaplasia and the molecular pathogenesis of intestinal metaplasia in antrum of stomach. Methods Light microscopy and immunohistochemical staining were used in this study. Types and degree of intestinal metaplasia, pericryptal fibroblast sheath( PCFs )and CDX2 expression were. observed in 99 cases of gastric hiopsies. Results The type of intestinal metaplasia was significantly different among groups with various degree of intestinal metaplasia. Slight intestinal metaplasia presented in more cases with type Ⅰ intestinal metaplasia than types Ⅱ and Ⅲ . And there were more cases with type Ⅲ in severe intestinal metaplasia( P ＜ 0. 001 ). In 99 cases of gastric mucosa samples of intestinal metaplasia.PCFs were recognized in 63 cases( 63. 6％ ). The development of PCFs was significantly correlated with the expression of CDX2( r= 0. 584 .P ＜ 0. 001 ). Conclusions The degree of intestinal metaplasia can properly reflect the type of intestinal metaplasia. It is very convenient to ohserve the degree of intestinal metaplasia with light microscope by pathologists. It may be accepted and widely used by clinicians to estimate the type of intestinal metaplasia and to decide if the patients need to he followed up according to the degree of intestinal metaplasia.关键词
胃黏膜/肠上皮化生/同源异形盒基因CDX2/pericryptal fibroblast sheath分类
医药卫生引用本文复制引用
刘杰英,韩艳春,杨东霞,刘鲁英..胃窦黏膜肠上皮化生类型与程度的关系及其临床意义[J].临床与实验病理学杂志,2011,27(2):134-137,4.
