广东医学2011，Vol.32Issue(1)：57-60,4.
难治复发性多发性骨髓瘤特点分析
Analysis of clinical features of patients with relapsing or refractory multiple myeloma
陈大燕 1冯茹 1张钰 1魏永强 1黄芬 1刘晓力 1徐兵 1孟凡义1
作者信息
- 1. 南方医科大学南方医院血液科,广州,510515
- 折叠
摘要
Abstract
Objective To study the clinical features and prognostic factors of patients with relapsing or refractory multiple myeloma ( MM ). Methods 53 previously untreated patients with MM, and diagnosed as refractory or relapsing MM with follow - up were included for retrospective analysis. Analysis was performed to evaluate the influence of known prognostic factors on prognosis between patients with TTP ＜ 1 year and ≥1 year. Results Of all the patients , 25 patients followed up died, 14 patients survived and 14 patients censored. Sacrodynia was the most common starting symptom ( 79. 2％ ), also in TTP ( 50. 9％ ). Patients with Durie - salmon Ⅲ stage accounted for 84. 9％ . There were 10 patients with extramedullary evolvemen and 1 patient with plasma cell leukemia. The median TTP, median follow - up time from progression and median follow - up time were 16. 0, 6. 0 and 29. 5 months, respectively. Patients with TTP ＜ 1 year and ≥1 year accounted for 21 and 32 among all patients. The median follow - up time and follow - up time from progression were 11. 0 months. 44. 0 months; and 4. 0 months, 12. 0 months, respectively. Conclusion Sacrodynia may be a sign of the disease progression in the patients with MM. High plasma cell count in bone marrow and short time to progression are negative factors for prognosis.关键词
多发性骨髓瘤/难治/多发性骨髓瘤/复发/临床表现/预后/进展引用本文复制引用
陈大燕,冯茹,张钰,魏永强,黄芬,刘晓力,徐兵,孟凡义..难治复发性多发性骨髓瘤特点分析[J].广东医学,2011,32(1):57-60,4.
