疑难病杂志2011，Vol.10Issue(4)：258-259,2.DOI:10.3969/j.issn.1671-6450.2011.04.006
急性脑梗死患者血浆溶血磷脂酸水平与颈动脉粥样硬化特点的观察
The relationship between changes of plasma lysophosphatidic acid level and carotid atherosclerosis in patients with acute cerebral infarction
吴晓燕1
作者信息
- 1. 274031,山东省菏泽市立医院神经内科
- 折叠
摘要
Abstract
Objective To study the levels of plasma lysophosphatidic acid ( LPA ) and its clinical significance in patients with acute cerebral infarction ( ACI ) and its relationship with carotid atherosclerosis ( CAS ). Methods All of the 180 ACI patients and the normal healthy group were tested by carotid ultrasonography. The intima-media thickness ( IMT ) of common carotid artery' s dist, the bifurcation of carotid artery and the origin of the internal carotid artery were recorded. The plaques and their size were measured, then determined whether there was CAS or not, then they were divided into the CAS group( n= 62, including 32 cases with vulnerable CAS and 30 cases with stable CAS ),intima thickening group( n= 48 ), and the normal group( n =70 ). Compared with the normal healthy group, LPA was measured in 180 ACI patients. Results The LPA of ACI patients rose in the acute phase. The ACI group compared with the normal healthy group has significant difference ( P ＜ 0.01 ). The LPA of the CAS group were higher than the other two groups( P ＜ 0.01 ). The plasma LPA in vulnerable CAS group were higher than that in stable CAS group( P ＜ 0.01 ). Conclusion The plasma LPA in the group of ACI was higher than the normal healthy group. The LPA might play a role in ACI development. There was a significant correlation between carotid atherosclerosis and LPA level in ACI.关键词
溶血磷脂酸/颈动脉粥样硬化斑块/脑梗死,急性引用本文复制引用
吴晓燕..急性脑梗死患者血浆溶血磷脂酸水平与颈动脉粥样硬化特点的观察[J].疑难病杂志,2011,10(4):258-259,2.
