疑难病杂志2011，Vol.10Issue(4)：293-295,封3,4.DOI:10.3969/j.issn.1671-6450.2011.04.020
三氧化二砷对人肝癌细胞生长及其侵袭转移能力的影响
Effect of arsenic trioxide on growth and invasion metastasis of human hepatocarcinoma
摘要
Abstract
Objective To investigate the effect of arsenic trioxide( As2 O3 ) in growth and adhesion as well as invasion metastasis of SMMC-7721 in human hepatocarcinoma in vitro. Methods Applying the MTT method to study the effect of growth and adhesion by As2O3 on SMMC-7721 cell. The transwell chamber membrane invasion culture system was used to study the invasion and metastasis. Results The As2O3 could significantly inhibit the SMMC-7721 cell growth, and inhibit the adhesion function with Matrigel. There was statistical difference between the similar action time with different concentration and the similar concentration with different action time( P ＜0. 01 ). The As2O3 could inhibit the cell migration through the basement membrane and movement function. Compared with the control group, the number of migration cell and invasion through the basement membrane was decreased( P ＜ 0.05 ). Conclusion The As2 O3 had the ability to inhibit the hepatocarcinoma cell growth as well as adhesion and invasion metastasis.关键词
肝癌/SMMC-7721细胞/三氧化二砷/黏附/侵袭引用本文复制引用
余桂芳,严跃红,陈益民..三氧化二砷对人肝癌细胞生长及其侵袭转移能力的影响[J].疑难病杂志,2011,10(4):293-295,封3,4.基金项目
广州市中医药科研项目资助(No.2010A34) （No.2010A34）
