疑难病杂志2011，Vol.10Issue(4)：278-281,4.DOI:10.3969/j.issn.1671-6450.2011.04.014
脂氧合酶-5及血管内皮生长因子在乳腺癌中的表达及临床意义
Expression and clinical significance of LOX-5 and VEGF in human breast cancer
丁佩剑 1杨阳 1王波 2冯佩明 1杨战军 3赵联志3
作者信息
- 1. 067000,承德医学院附属医院
- 2. 河北省承德市卫生监督所
- 3. 承德医学院
- 折叠
摘要
Abstract
Objective To investigate the expression of LOX-5 and VEGF in breast cancer and analyze the effect of LOX-5, VEGF in breast cancer development and its relationship with clinicopathological factors. Methods LOX-5 and VEGF expression were detected by immunohistochemistry in 60 cases of breast cancer, 20 cases of breast fibroadenoma and 20 cases of adjacent normal tissue. Correlation with the clinical pathology were analyzed. Results LOX-5 positive expression rate was 85.0％ in 60 cases of breast cancer, which was higher than adjacent tissues ( 15.0％ ) and fibroadenoma of breast tissue ( 5.0％ )( P ＜ 0.05 ); VEGF positive expression rate was 81.7％ in 60 cases of breast cancer, which was significantly higher than adjacent tissues ( 35.0％ ) and fibroadenoma of breast tissue ( 20.0％, P ＜ 0.05 ). LOX-5 and VEGF expression were correlated with tumor size, histological grade, clinical stage, lymph node metastasis( P ＜0.05, P ＜0.01 ), but were not correlated with age, estrogen and progesterone receptor. The Spearman rank correlation test suggested that LOX-5 was positively correlated with VEGF expression( r =0. 5151, P ＜0.01 ). Conclusion Low expression of LOX-5, VEGF were found in breast fibroadenoma tissue and adjacent tissues, high expression were found in breast cancer, which indicates high expression was correlated with tumor invasion, metastasis and other factors related to poor prognosis.关键词
乳腺癌/脂氧合酶-5/血管内皮生长因子/免疫组化引用本文复制引用
丁佩剑,杨阳,王波,冯佩明,杨战军,赵联志..脂氧合酶-5及血管内皮生长因子在乳腺癌中的表达及临床意义[J].疑难病杂志,2011,10(4):278-281,4.
