西安交通大学学报（医学版）2011，Vol.32Issue(1)：47-49,3.
Nbn基因对小鼠海马神经元发育的影响
Effect of Nbn gene on the development of mouse hippocampus neurons
张莉 1张蕊 1郭敏1
作者信息
- 1. 辽宁医学院组织胚胎学教研室,辽宁锦州,121001
- 折叠
摘要
Abstract
Objective To investigate the role of Nbn gene in the development of hippocampus neurons in Nbn gene neuro-specific deleted (Nbn-CNS-del) mice.Methods NeuN monoclonal antibody, HE staining, immunohistochemical and stereologicai methods were used to analyze the morphological changes of hippocampus neurons in Nbn-CNS-del mice and Nbn gene undeleted mice (control group) on P7, 14 and 21 days.Results Compared with those in control group, the profile areas of molecular layer, granular cell layer and/or pyramidal cell layer, and polymorphic layer of hippocampus in Nbn-CNS-del mice were all reduced (P ＜ 0.01); the profile numerical densities of NeuN positive cells in granular cell layer and/or pyramidal cell layer were significantly decreased, too (P ＜ 0.01).Conclusion The development of hippocampus neurons in Nbn-CNS-del mice is inhibited and Nbn may be an important gene during the development of hippocampus neurons.关键词
Nbn基因/海马/神经元/发育/小鼠分类
医药卫生引用本文复制引用
张莉,张蕊,郭敏..Nbn基因对小鼠海马神经元发育的影响[J].西安交通大学学报（医学版）,2011,32(1):47-49,3.
