疑难病杂志2011，Vol.10Issue(4)：270-272,3.DOI:10.3969/j.issn.1671-6450.2011.04.010
乳果糖联合培菲康对肝硬化自发性细菌性腹膜炎患者肠黏膜屏障功能及炎性细胞因子的影响
The clinical effect of lactulose and bifid lriple viable on intestinal barrier function and inflammatory cytokine in cirrhosis patients with spontaneous bacterial peritonitis
储建坤 1茹秀丽 1杨涛 1张征 1霍晓辉 1马金城1
作者信息
- 1. 050031,石家庄,河北医科大学第一医院消化内科
- 折叠
摘要
Abstract
Objective To evaluate the effects of lactulose and bifid lriple viable on intestinal barrier function, serum and ascites TNF-α, interleukin-6 levels in hepatitis cirrhotic patients with spontaneous bacterial peritonitis ( SBP ).Methods One hundred and twenty- SBP patients with hepatitis cirrhosis were randomly allocated into two groups, treatment group( n =60 ) and control group( n = 60 ).Health volunteers were selected as healthy control group( n = 30 ).All subjects were observed for 7days.To evaluate intestinal perneability, the concentration of lactulose( LAC )and mannitol( MAN ) in urine was measured using high pressure liquid chromatograph with refractive index detector ( HPLC RID ), the concentration of serum and ascites TNF-α and interleukin-6 were measured before and after seven day-s of treatment with lactulose and bifid lriple viable, and mortality rate of patients was counted.Results The levels of urinary- excretion of LAC/MAN ratios, serum and ascires TNF-α and interleukin-6 levels in treatment group and control group were significantly higher than of healthy control group ( P ＜ 0.05 or P ＜ 0.01 ); the levels of urinary excretion of LAC/MAN ratios, serum and ascites TNF-α and interleukin-6 levels after treatment in treatment group were significantly lowered than that of control group( P ＜ 0.05 or P ＜ 0.01 ); the mortality rate of treatment group was significantly lowered than that of control group( 8.33 ％ vs 18.33 ％, P ＜ 0.05 ).Conclusion The treatment combined with lactulose and bifid lriple viable can effectively reduce serum and ascites TNF-α and interleukin-6 levels, improve intestinal barrier function and prognosis.关键词
乳果糖/双歧杆菌/肝硬化/腹膜炎,细菌性,自发性/细胞因子引用本文复制引用
储建坤,茹秀丽,杨涛,张征,霍晓辉,马金城..乳果糖联合培菲康对肝硬化自发性细菌性腹膜炎患者肠黏膜屏障功能及炎性细胞因子的影响[J].疑难病杂志,2011,10(4):270-272,3.
