西安交通大学学报（医学版）2011，Vol.32Issue(1)：6-9,4.
Fas、FasL在非小细胞肺癌中的表达及其与肿瘤免疫和细胞凋亡的关系
Expression of Fas/FasL protein and its relationship with tumorigenesis immunology and apoptosis in non-small cell lung cancer
刘颖 1吴金如 2高元勋1
作者信息
- 1. 郑州大学第二附属医院呼吸内科,河南郑州,450014
- 2. 襄樊市中心医院呼吸内科,湖北襄樊,445000
- 折叠
摘要
Abstract
Objective In order to provide evidence for early diagnosis, prognosis prediction and new treatment of lung cancer,we analyze the immune escape of the Fas/FasL system in the carcinogenesis and progress of non-small cell lung cancer (NSCLC). Methods Immunohisochemistry (IHC) method was used to determine the expression of Fas/FasL protein in NSCLC and normal lung tissues; CD45RO antibody and TUNEL technique were used to detect the tumor infiltrating lymphocytes (TILs) and apoptosis respectively. Results Fas expression was found to be significantly reduced in cancer tissues, and it was correlated with the degree of tissue differentiation.There was a high level of FasL expression in cancer tissues. The expression rate of FasL was correlated with the cell type and lymph node metastasis, and negatively correlated with TIL infiltration degree. Fas expression had no association with the apoptosis level of cancer cells. Conclusion Reduced or absent expression of Fas and increased FasL expression are common in NSCLC tissues, which leads to the escape of cancer cells from immunosurveillance and thus the carcinogenesis and development of NSCLC.关键词
Fas/FasL/肿瘤组织中浸润淋巴细胞/免疫组化/CD45RO/非小细胞肺癌/细胞凋亡/TUNEL/免疫逃逸分类
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刘颖,吴金如,高元勋..Fas、FasL在非小细胞肺癌中的表达及其与肿瘤免疫和细胞凋亡的关系[J].西安交通大学学报（医学版）,2011,32(1):6-9,4.
