西安交通大学学报（医学版）2011，Vol.32Issue(1)：34-37,4.
CYFRA21-1对早期非小细胞肺癌诊断价值的Meta分析
Meta-analysis on the diagnostic value of CYFRA21-1 in early non-small cell lung cancer
刘延峰 1杨拴盈 1尚文丽 1张薇 1霍淑芬 1卜丽娜 1戎彪学 1南岩东 1田应选1
作者信息
- 1. 西安交通大学医学院第二附属医院呼吸内科,陕西西安,710004
- 折叠
摘要
Abstract
Objective To evaluate the diagnostic value of CYFRA21-1 in early non-small cell lung cancer (NSCLC). Methods All published clinical studies that evaluated the diagnostic value of CYFRA21-1 in non-small cell lung cancer were reviewed. The quality of the retrieved original studies was evaluated according to the requirements of meta-analysis. Meta-analysis was used in all eligible studies. Results Nine studies including six in Chinese and three in English were collected. The sample size was 670 cases, of which 276 cases confirmed pathologically were in stage Ⅰ - Ⅱ and resectable. Heterogeneity test showed that the homogeneity of the studies was good. Deterministic model was used to analyze the data. The value of the weighted sensitivity was 41％ (35 ％-46％), the specificity was 94％ (91％-96％), the positive likelihood ratio was 5.65 (3.45-9.27), the negative likelihood ratio was 0.64 (0.54-0.76), and the SROC area under the curve (AUC) was 0.85. (Conclusion CYFRA21-1 can be regarded as a valuable marker in early NSCLC diagnosis; however, but more high-quality, largesized and multi-center studies are still required to evaluate its clinical value.关键词
CYFRA21-1/非小细胞肺癌/Meta分析分类
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刘延峰,杨拴盈,尚文丽,张薇,霍淑芬,卜丽娜,戎彪学,南岩东,田应选..CYFRA21-1对早期非小细胞肺癌诊断价值的Meta分析[J].西安交通大学学报（医学版）,2011,32(1):34-37,4.
