西安交通大学学报（医学版）2011，Vol.32Issue(1)：65-68,4.
皮肤衰老进程中大鼠角质形成细胞的凋亡及松花粉的干预作用
Apoptosis changes of rat keratinocytes during skin aging and the interventional effect of pollenpini on aging process
杨帆 1马慧群 1曾维惠 1董妍 1郑雯1
作者信息
- 1. 西安交通大学医学院第二附属医院皮肤科,陕西西安,710004
- 折叠
摘要
Abstract
Objective To observe the apoptosis rate of keratinocytes in aging rats and the interventional effect of pollenpini on apoptosis. Methods The keratinocytes derived from SD rat back skin were used as the studied cells and observed by terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling (TUNEL) for the apoptosis rate differences between rats of different age and the pollenpini-fed aged group. Results The apoptosis rate in the infant group, adult group, aged group and the pollenpini-fed aged group was (73.549 50±4.43768)％, (59.509 10±4.781 50)％, (88.97800±3.70225)％ and (61.82000±7.784 60)％, respectively. The apoptosis rate in the infant group fell between those in the adult group and the aged group, and the apoptosis rate in the aged group was the highest (P＜0.01). Compared to that in the aged group, the apoptosis rate in the pollenpinifed aged group decreased significantly (P ＜ 0.01). Conclusion With aging the apoptosis of keratinocytes gradually increases, and pollenpini has a certait anti-aging effect.关键词
角质形成细胞/凋亡/松花粉/皮肤衰老分类
医药卫生引用本文复制引用
杨帆,马慧群,曾维惠,董妍,郑雯..皮肤衰老进程中大鼠角质形成细胞的凋亡及松花粉的干预作用[J].西安交通大学学报（医学版）,2011,32(1):65-68,4.
