中国全科医学2011，Vol.14Issue(8)：834-836,3.
阿替普酶溶栓后抗凝治疗对急性脑梗死患者的疗效及安全性
The Effectiveness and Safety of Heparin in Treatment of Acute Cerebral Infarction after Alteplase Thrombolysis
吕宪民 1曹亦宾 1李欣 1王海英 1马建国1
作者信息
- 1. 063000,河北省唐山市工人医院神经内科二病区
- 折叠
摘要
Abstract
Objective To Evaluate the effectiveness and safety of alteplase combined with heparin in treatment of a-cute cerebral infarction. Methods 70 hemispheric infarction inpatients received alteplase treatment in Neurology department of Tang Shan Worker Hospital from January 2007 to July 2010 were retrospectively analyzed. The patients were divided into two groups ( treatment and control group ) according to whether or not receiving heparin treatment. Demographic features and infarction areas were collected, as well as the NIHSS scores and mRS scores ( modified Rankin Scale ) before and after thrombolysis on 24h, the 7th day and 14th day. Mortality and mRS scores within 30 days were assessed by the symptomatic cerebral hemorrhage. Results There was no statistical difference in NIHSS scores between the two groups before and after thrombolysis ( P ＞0. 05 ). After thrombolysis, the NIHSS score at 7th and 14th day was less than that of control group. There was statistically significant difference ( P ＜0. 05 ). According to the mRS scores at 30th day, there were 18 cases ( 52. 9％ ) in treatment group and 10 cases ( 27. 8％ ) in control group with good neural prognosis ( mRS 0-2 ). There was statistically significant difference ( u = 380. 0, P ＜0. 05 ). Within 30 days, there were 2 death cases in treatment group, as well in control group. The mortality was 5. 9％ and 5. 5％ , respectively. There was no statistically significant difference ( x =0. 003, P ＞0. 05 ). There were 2 cases in treatment group ( 5. 9％ ) and 3 cases in control group ( 8. 3％ ) showed symptoms of intracerebral hemorrhage within 30 days. There was no statistically significant difference ( x2= 0. 158, P ＞ 0. 05 ). Conclusion Anticoagulation therapy after intravenous thrombolysis of acute cerebral infarction improves neurological function without increasing symptomatic intracranial hemorrhage and mortality.关键词
急性脑梗死/阿替普酶/溶栓/抗凝药/治疗结果分类
医药卫生引用本文复制引用
吕宪民,曹亦宾,李欣,王海英,马建国..阿替普酶溶栓后抗凝治疗对急性脑梗死患者的疗效及安全性[J].中国全科医学,2011,14(8):834-836,3.
