Abstract
Objective To study the levels of serum glutathione peroxidase ( GSH - PX ), superoxide dismutase ( SOD ) and malonyldialdehyde ( MDA ) in patients with essential hypertension ( EH ) complicated by impaired glucose tolerance ( IGT ) so as to investigate the relationships of lipid peroxidation with EH, IGT, and EH with IGT. Methods Totally 82 EH patients in whom 40 with normal glucose tolerance ( NGT ) and 42 with IGT, and 80 non — EH patients in whom 40 with NGT and 40 with IGT were recruited. The levels of GSH-PX, SOD and MDA were measured by using chemically colorimetric method. Results MDA levels ( μmol/L ) were higher in EH + IGT group than in non - EH + IGT group ( 22. 37 ± 1. 28 vs 18. 21 ± 1. 75 ), GSH levels ( μmol/L ) were lower in EH + IGT group than in non - EH + IGT group ( 0. 16 ± 0. 03 vs 0. 19 ± 0. 04 ), SOD levels ( U/mL ) were lower in EH + IGT group than in non - EH + IGT group ( 54. 31 ±6. 26 vs 60. 56 ±9. 18 ). And in all the 82 IGT patients, MDA level was positively correlated with the levels of systolic blood pressure ( SBP ), diastolic blood pressure ( DBF ), 2 - h postprandial blood glucose ( 2hPG ), HOMA insulin resistance index ( HOMA - IR ), and body mass index ( BMI ); SOD level was negatively correlated with levels of SBP, DBF, and 2hPG; and glutathione ( GSH ) level was negatively correlated with the SBP level, and positively with the levels of fasting plasma glucose ( FPG ), 2hPG, HOMA-IR, and BMI. In all the 80 IGT patients, MDA level was positively correlated with the levels of SBP, DBF, FPG, HOMA-IR, and BMI; SOD level was negatively correlated with SBP and DBP, and positively with FPG level; and GSH level was negatively correlated with the levels of SBP and DBP, and positively with the levels of FPG, HOMA-IR, and BMI. Multivariate Logistic a-nalysis showed that EH complicated by IGT was positively correlated with MDA, GSH, SOD, FPG, 2hPG, BMI, SBP and DBP (β = 0. 064, - 0. 127, - 0. 630, 0. 098, 1. 674, 0. 142, 0. 247, 0. 074, respectively, P＜0. 05 ) . Conclusion In patients with EH, IGT, and EH complicated by IGT. the serum level of MDA is increased, the levels of GSH and SOD are decreased. This indicates that the EH and IGT patients have an enhanced lipid peroxidation level.关键词
原发性高血压合并糖耐量减低/超氧化物歧化酶/谷胱甘肽过氧化物酶/丙二醛分类
医药卫生
