中国全科医学2011，Vol.14Issue(9)：1006-1007,1010,3.
神经节苷脂对神经元特异性烯醇化酶阳性的宫内发育迟缓儿的疗效观察
Curative Effect of Ganglioside on Neuron-specific Enolase Positive Intrauterine Growth Retardation
胡坚锋1
作者信息
- 1. 315300,浙江省慈溪市人民医院儿内科
- 折叠
摘要
Abstract
Objective To explore the effect of ganglioside ( CM1 ) on the prognosis of neuron - specific enolase ( NSE ) positive intrauterine growth retardation ( IUGR ) in early comprehensive intervention. Methods Umbilical cord blood was collected instantly at expulsion in newborns born in our hospital from January 2005 to Octoher 2007. Enzyme - linked immunosorhent assay ( ELISA ) was used to detect NSE level. Fifty - four newborns with elevated NSE were divided into groups intervention ( n = 29 . receiving GM1 ) and control ( n = 25 ). Both groups received early intervention and rehabilitation and intervention group given additional GM1 , 20 mg/d, iv , 3 -6 courses of treatment ( 10 d as a course of treatment ). Neonatal behavioral neurological assessment ( NBNA ) was used to score during neonatal period , and post - interventional mental development index ( MPl ) and psychomotor development index ( PDE ) were evaluated at ages of years 1 , 2. Results MDI and PDI were significantly higher in intervention group than in control at ages of years 1 , 2 ( P ＜0. 01 ). The occurrence of sequela was 6. 8％ in intervention group, 25. 2％ in control, the difference was significant ( P ＜ 0. 05 ). Conclusion NSE level is related to hrain injuries. Early GM1 intervention can promote intelligence development, prevent and reduce neurological sequela and improve prognoses of IUGR.关键词
神经节苷脂/神经元特异性烯醇化酶/宫内发育迟缓儿/综合干预分类
医药卫生引用本文复制引用
胡坚锋..神经节苷脂对神经元特异性烯醇化酶阳性的宫内发育迟缓儿的疗效观察[J].中国全科医学,2011,14(9):1006-1007,1010,3.
