浙江医学2011，Vol.33Issue(3)：312-315,4.
ESWL和URS-PL对输尿管下段结石患者红细胞免疫功能、T细胞亚群及NK细胞的影响
Changes of immune indicators after extracorporeal shock wave lithotripsy and ureteroscopy and pneumatic lithotripsy in patients with distal ureteral calculi
摘要
Abstract
Objective To investigate the immune indicators after extracorporeal shock wave lithotripsy (ESWL) and ureteroscopy and pneumatic lithotripsy (URS- PI) in patients with distal ureteral calculi. Methods From Jan 2009 to Jul 2009, 61 patients with distal ureteral stone were divided into two groups randomly: 31 patients were treated with ESWL and other 30 patients were treated with URS- PL. Blood samples were collected 1d before operation, 30 min, 1d and 4d after operation respectively. Immune function of erythrocyte, T lymphocyte subsets (CD3, CD4 and CD8), CD4/CD8 ratio and natural killer cells (NK cells) were measured by flow cytometry. T cell proliferation assay and the cytotoxic activities of the NK cells were assessed with the thiazolyl blue tetrazolium bromide (MTT) method. Results Compared with 1d before operation and ESWL group, the percentage of CD3 and CD4 T lymphocytes, CD4/CD8 rati ofURS- PL group 1 d after operatinn were significantly decreased (P＜0.05 or 0.01); the cytotoxic activities of the NK cell were significantly decreased 30min and 1d after operation (P＜0.05 or 0.01); RBC C 3b receptor rosette (RCRR), RBC immune complex rosette (RICR) and tumor RBC rosette (TRR) were significantly decreased 30min, 1d and 4d after operation (P＜0.05 orP＜0.01). Conclusion Compared with URS- PL, ESWL may have less effects on immune function oferythrocyte, T lymphocyte subsets and natural killer cells in the treatment of distal ureteral calculi.关键词
输尿管结石/输尿管镜/碎石术/T淋巴细胞/红细胞免疫/NK细胞引用本文复制引用
李俊龙,阎家骏,陈炜..ESWL和URS-PL对输尿管下段结石患者红细胞免疫功能、T细胞亚群及NK细胞的影响[J].浙江医学,2011,33(3):312-315,4.基金项目
绍兴市科技计划重点项目(2008A23007) （2008A23007）
