中国药理学通报2011，Vol.27Issue(4)：515-518,4.DOI:10.3969/j.issn.1001-1978.2011.04.018
奥沙利铂长循环热敏脂质体及其药效学研究
Preparation and initial efficacy of oxaliplatin long-circulating thermosensitive liposomes
摘要
Abstract
Aim To prepare oxaliplatin longiirculating-thermosensitive liposomes (OLTL) and study the nature and the anti-tumor effects of OLTL. Methods The thin film hydration method was used to prepare OLTL. The release behavior of the drug at 37℃ and 42℃ from liposome was investigated by the dialysis method. The anti-tumor activity was observed using the weight of tumor as an index. Results The particle size of the liposome was between lOOnm and 130nm.The drug encapsulation efficiency exceeclecl 90％ . The release ratio of OLTL in vitro was more than 90％ at 42℃. OLTL group possessed the inhibitory ratio of 70. 79％ . Conclusion OLTL has obvious thermosensitive feature , which combined with local hyperthermia can significantly increase the anti-tumor effects of oxaliplatin.关键词
奥沙利铂/长循环/热敏/脂质体/药效分类
医药卫生引用本文复制引用
畅敏,华海婴,贾丽敏,梅兴国,赵永星..奥沙利铂长循环热敏脂质体及其药效学研究[J].中国药理学通报,2011,27(4):515-518,4.基金项目
国家"重大新药创制"科技重大专项资助项目(No 2009ZX09301-002) （No 2009ZX09301-002）
