中国药理学通报2011，Vol.27Issue(4)：558-561,4.DOI:10.3969/j.issn.1001-1978.2011.04.027
荆芥内酯在大鼠体内的药物动力学及生物利用度
A study of pharmacokinetics and absolute bioavailability of schizonepetin in rats
摘要
Abstract
Aim To investigate the pharmacokinetic characteristics of schizonepetin and its bioavailability in rats. Methods An HPLC method was established to analyze the plasma concentration of' schizonepetin with different intragastric and intravenous administration doses to rats. Pharmacokinetic parameters were calculated by noncompartmental model in Kinetica 4. 4. Results The Cmax and AUC0-∞ showed non-linearrelation after intragastric administration of 47. 87 ,23. 94 and 11. 97 mg' kg - 1 . The Cmax and AUC0-∞ after intravenous administration of 11. 97 mg · kg-1 were 6. 5 mg · L-1 and 18 mg· h· L-1. And the absolute bioavailability was 69. 1 ％. Conclusion This method for the pharmacokinetic and absolute bioavailability study of schizonepetin in rats is simple , rapid and accurate.关键词
荆芥内酯/大鼠/血药浓度/药代动力学/生物利用度/HPLC/吸收分类
医药卫生引用本文复制引用
孙熠,耿婷,姚卫峰,丁安伟,张丽..荆芥内酯在大鼠体内的药物动力学及生物利用度[J].中国药理学通报,2011,27(4):558-561,4.基金项目
国家科技重大专项课题创新药物研究开发-候选药物研究(No 2009ZX09103-339) （No 2009ZX09103-339）
