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下调PCNA和VCAM-1表达参与山柰酚抑制人前列腺癌细胞增殖

仇炜雷宇华苏明李冬军张宁沈永青

中国药理学通报2011，Vol.27Issue(4)：553-557,5.

中国药理学通报2011，Vol.27Issue(4)：553-557,5.DOI:10.3969/j.issn.1001-1978.2011.04.026

下调PCNA和VCAM-1表达参与山柰酚抑制人前列腺癌细胞增殖

Kaempferol inhibits proliferation of human prostate cancer PC-3 cells via down-regulation of PCNA and VCAM-1

仇炜 ¹雷宇华 ²苏明 ²李冬军 ³张宁 ⁴沈永青²

作者信息

1. 河北医科大学附属第四医院泌尿外科,河北,石家庄,050011
2. 河北医科大学,河北,石家庄,050017
3. 河北医科大学附属人民医院,河北,石家庄,050011
4. 河北医科大学附属第二医院,河北,石家庄,050000
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摘要

Abstract

Aim To investigate the effects of kaempferol on the inhibition of the proliferation of human prostate cancer PC-3 cells. Methods MTT assays, cell counting ancl flow cytometry were performecl to investigate the effects of kaempferol on proliferation and apoptosis of PC -3 cells. Western blot assays were performed to analyze the expression of PCNA and VCAM -1. Results Kaempferol inhibited proliferation of PC-3 cells, and decreased the expression of PCNA and VCAM-I. Kaempferol induced S and G2/M phase cell cycle arrest to PC-3 cells, but did not significantly affect apoptosis. Conclusion Kaempferol induces S and G2/M phase cell cycle arrest ancl inhibits proliferation of PC-3 cells via down-regulation of PCNA and VCAM-1.

关键词

山柰酚/前列腺癌/增殖/细胞周期/细胞凋亡/血管细胞黏附分子1/增殖细胞核抗原

分类

医药卫生

引用本文复制引用

仇炜,雷宇华,苏明,李冬军,张宁,沈永青..下调PCNA和VCAM-1表达参与山柰酚抑制人前列腺癌细胞增殖[J].中国药理学通报,2011,27(4):553-557,5.

基金项目

河北省科技支撑项目(No 08206117D) （No 08206117D）

河北省医学科学研究重点课题计划指导项目(No 08259) （No 08259）

中国药理学通报

OA北大核心CSCDCSTPCD

ISSN：1001-1978

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