中国药理学通报2011，Vol.27Issue(1)：1-4,4.
GXXXG结构对老年性痴呆相关蛋白功能调节研究进展
Research progress about the regulation of GXXXG structures in the Alzheimer-related protein
摘要
Abstract
As a key factor of Alzheimer,s disease( AD ) , β-amyloid( Aβ)has emerged as an attractive drug target.Aβ species produced inhibitor is one of the most important aspects in antiAD drug researc:h and developement.Recent advances showed that some Aβ-related proteins, including β-amyloid precursor protein( APP ), γ-secretase complex PS-1 andAPH-1, have a special structure in transmembrane sequence( TMS ), an aminoacid motif GXXXG,which has a regulatory impact on Aβ species production and aggregation.This paper describes the regulation of GXXXG structure to the function of AD-related proteins,which may hold the promise for the development of anti-AD drugs.关键词
GXXXG结构/Aβ生成/Aβ聚集/老年性痴呆/淀粉样前体蛋白/γ分泌酶分类
医药卫生引用本文复制引用
吴彦霖,辛晓洁,辛现良,耿美玉..GXXXG结构对老年性痴呆相关蛋白功能调节研究进展[J].中国药理学通报,2011,27(1):1-4,4.基金项目
国家杰出青年科学基金资助项目(No 30725046) （No 30725046）
