中国药理学通报2011，Vol.27Issue(1)：140-142,3.
SIRT1与成体干细胞衰老
SIRT1 and adult stem cell senescence
摘要
Abstract
stem cells differentiate into a variety of somatic cells which perform particular functions, in order to maintain integrity of specific tissues and organs during their lifespan. Studies have shown that senescence, which contributes to aging and the weakness under stress, occurs in adult stem cells. Sirtuins 1( SIRT1 ) is a NAD + -dependent deacetylase in mammalian cells. Activated SIRT1 may have anti-senescence effects on somatic cells, as well as in adult stem cells through balancing stem cell quiescence and proliferation, maintaining self-renewal capacity, ameliorating age-related decline in stem cell function and diminishing differentiation bias. Molecular mechanisms underlying SIRT1 anti-senescence ability still require to be investigated.关键词
SIRT1/去乙酰化/成体干细胞/衰老/静息态/自我更新/分化分类
医药卫生引用本文复制引用
翟志斌,孟爱民..SIRT1与成体干细胞衰老[J].中国药理学通报,2011,27(1):140-142,3.基金项目
国家自然科学基金资助项目(No 81072237) （No 81072237）
国家重点基础研究发展计划(973计划)资助项目(No 2011CB964800) （973计划）
