中国药理学通报2011，Vol.27Issue(2)：167-174,8.
头孢曲松对甲基苯丙胺致大鼠行为及纹状体氨基酸等递质含量改变的影响
The role of ceftrixone on methamphetamine induced behavior and amino acids in striatum
摘要
Abstract
Aim To observe the neuro-injury induced by methamphetamine( METH )acute treatment and to investigate changes of glutamate and dopamine on METH-induced nerve injury in striatum.Methods Rats were administered( ip )with METH to establish acute toxicity model, and the glutamate transporter agonist ceftriaxolne( Cef )was applied to regulate the expression of glutamate transporters.The neurotoxicity of METH was evaluated by stereotyped behavior.And the concentration of Glu , Gly , and DA in striatum were detected by microdialysis combined with HPLC-FD method.Results Brain microdialysis and high performance liquid results showed that, after acute administration of METH , extracellular Glu concentration was increased continuously during the whole detection time( 0～ 6 h ), compared with the basal level, extracellular glutamate concentrations increased 450％ at 5.5 h after METH administration.And DA concentration reached peak level at1 h , compared with the basal level, extracellular DA concentrations increased 1248.6％ at 1 h.Compared to METH group, pretreated with ceftrixone significantly decreased the extracellular Glu concentration in striatum( P ＜0.05 ).The DA concentration at 1 h was partly inhibited.but it still increased 838.4％ compared with the basal level.Conclusions Neurotoxicity of METH was closely related to excessive release of excitatory amino acids.Glutamate transporter may be a drug target for controlling METH-induced neurotoxicity.关键词
头孢曲松/甲基苯丙胺/纹状体/谷氨酸/γ-氨基丁酸/多巴胺分类
医药卫生引用本文复制引用
李成敏,颜慧,高文静,刘丽宏,宫泽辉..头孢曲松对甲基苯丙胺致大鼠行为及纹状体氨基酸等递质含量改变的影响[J].中国药理学通报,2011,27(2):167-174,8.基金项目
国家重点基础研究发展计划(973计划)资助项目(No 2003CB515400,2009CB522000) （973计划）
