中国药理学通报2011，Vol.27Issue(2)：174-177,4.
松果菊苷对脑缺血大鼠纹状体细胞外液中单胺类神经递质的影响
Effects of echinacoside on striatal extracellular levels of monoamine neurotransmitter in cerebral ischemia rats
摘要
Abstract
Aim To examine the effects of ECH on striatal extracellular levels of NE, DA, DOPAC, HIAA, HVA,5-HT in cerebral ischemia rats and its possible mechanisms of neuro-protective effect. Methods Rats were divided into control, model, ECH high and low dose and CXQ groups randomly. Every rat was administered drugs or vehicle through introperitoneal injection, one time a day for seven consecutive days. At day 3 focal ischemia was generated by permanent middle cerebral artery occlusion( MCAO ). Then the striatal extracellular fluids were gained by brain microdialysis. The methods of high performance liquid chromatography with electrochemical detection were used to measure the striatal extracellular levels of NE, DA, DOPAC, HIAA, HVA, 5-HT. Results The results showed that the level of NE, DA ,5-HT increased rapidly, and sodid its metabolites DOPAC, HIAA, HVA accordingly. Compared with model, administration of ECH and CXQ successfully prevented the extracellular levels of NE, DA, DOPAC, HIAA, HVA, 5-HT from elevation induced. Conclusion ECH can reduce monoamine neurotrans-mitters and their metabolites content of striatal extracellularlevels, which may be one of the mechanisms of anti-cerebral ischemia.关键词
松果菊苷/脑缺血/纹状体/HPLC-ECD/单胺类神经递质及代谢产物分类
医药卫生引用本文复制引用
魏丽丽,陈虹,姜勇,屠鹏飞,钟明,杜娟,刘斐,刘春阳,王磊..松果菊苷对脑缺血大鼠纹状体细胞外液中单胺类神经递质的影响[J].中国药理学通报,2011,27(2):174-177,4.基金项目
国家自然科学基金资助项目(No 30860334,30560171) （No 30860334,30560171）
