中国药理学通报2011，Vol.27Issue(1)：54-58,5.
西维来司钠对大鼠脑缺血/再灌注损伤的保护作用及机制
Protective effects of sivelestat sodiurm on cerebral ischemia-reperfusion injury in rats and its mechanism
摘要
Abstract
Aim To investigate the protective effect of sivelestat sodiurm( SIV ) on cerebral ischemia-reperfusion injury in rats and its mechanism.Methods 90 rats were randomly divided into 6 groups: sham operation group , model group and 10 , 30 , 90 mg · kg -1 SIV groups , with 15 rats in each group.The model of focal cerebral ischemia-reperfusion in rats was established with modified sutured-occluded method.The rats in SIV groups were injected with SIV at the matched concentration.The rats in sham operation group and model group were injected with saline.And all rats were given more time in 3 hours.6 hours after ischemia.Rats were sacrificed for histologic examination after the behavioral test,and their brains were taken to assay the activities of SOD.MDA.MPO , the content of NE and the expression of Caspase-1( ICE )and Caspase-3.Results SIV at different dosages( 10 , 30 ,90 mg·kg -1 )could obviously decrease neurological deficit score, repair histological injury, and reduce the activities of SOD, MDA and MPO in rats of focal cerebral ischemia-reperfusion injury , and attenuate the expression of Caspase-1( ICE ) and Caspase-3.Conclusion SIV can relieve the cerebral ischemia reperfusion injury, and its mechanism may be partly related to its effects of antiinflammation and antioxidation.关键词
西维来司钠/脑缺血/再灌注/保护作用/抗炎/抗氧化/中性粒细胞弹性蛋白酶/Caspase-3/Caspase-1(ICE)分类
医药卫生引用本文复制引用
丁丽君,董志,乐乐乐,秦黄英..西维来司钠对大鼠脑缺血/再灌注损伤的保护作用及机制[J].中国药理学通报,2011,27(1):54-58,5.基金项目
国家自然科学基金资助项目(No 30572074) （No 30572074）
