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Traumatic brain injury impairs synaptic plasticity in hippocampus in rats

ZHANG Bao-liang CHEN Xin TAN Tao YANG Zhuo CARLOS Dayao JIANG Rong-cai ZHANG Jian-ning

中华医学杂志（英文版）2011，Vol.124Issue(5)：740-745,6.

中华医学杂志（英文版）2011，Vol.124Issue(5)：740-745,6.DOI:10.3760/cma.j.issn.0366-6999.2011.05.020

Traumatic brain injury impairs synaptic plasticity in hippocampus in rats

ZHANG Bao-liang ¹CHEN Xin ²TAN Tao ³YANG Zhuo ⁴CARLOS Dayao ¹JIANG Rong-cai ²ZHANG Jian-ning³

作者信息

1. Department of Neurosurgery, Tianjin Medical University General Hospital
2. Tianjin Neurological Institute
3. Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education
4. Tianjin Key Laboratory of Injuries, Varia
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摘要

Abstract

Background Traumatic brain injury (TBl) often causes cognitive deficits and remote symptomatic epilepsy.Hippocampal regional excitability is associated with the cognitive function. However, little is known about injury-induced neuronal loss and subsequent alterations of hippocampal regional excitability. The present study was designed to determine whether TBl may impair the cellular circuit in the hippocampus.Methods Forty male Wistar rats were randomized into control (n=20) and TBl groups (n=20). Long-term potentiation,extracellular input/output curves, and hippocampal parvalbumin-immunoreactive and cholecystokinin-immunoreactive interneurons were compared between the two groups.Results TBI resulted in a significantly increased excitability in the dentate gyrus (DG), but a significantly decreased excitability in the cornu ammonis 1 (CA1) area. Using design-based stereological injury procedures, we induced interneuronal loss in the DG and CA3 subregions in the hippocampus, but not in the CA1 area.Conclusions TBl leads to the impairment of hippocampus synaptic plasticity due to the changing of interneuronal interaction. The injury-induced disruption of synaptic efficacy within the hippocampal circuit may underlie the observed cognitive deficits and symptomatic epilepsy.

关键词

traumatic brain injury/long-term potentiation/hippocampus/dentate gyrus/cornu ammonis 3 area

Key words

traumatic brain injury/long-term potentiation/hippocampus/dentate gyrus/cornu ammonis 3 area

引用本文复制引用

ZHANG Bao-liang,CHEN Xin,TAN Tao,YANG Zhuo,CARLOS Dayao,JIANG Rong-cai ,ZHANG Jian-ning..Traumatic brain injury impairs synaptic plasticity in hippocampus in rats[J].中华医学杂志（英文版）,2011,124(5):740-745,6.

基金项目

This work was supported by grants from the National "973 Projects" of China (No. 2005CB522605), Tianjin Science and Technology Development Plan (No. 05YFGDSF02500) and Tianjin Natural Science Foundation (No. 033611511). （No. 2005CB522605）

中华医学杂志（英文版）

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ISSN：0366-6999

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