中国全科医学2011，Vol.14Issue(12)：1314-1317,4.
Bcl-2和Bag-1在结肠癌组织中的表达及其意义
Expressions of Bcl-2 and Bag-1 in Colon Carcinoma and Its Significance
兰涛 1张金生 1任俊华 1苑建磊1
作者信息
- 1. 061000河北省沧州市,南方医科大学附属沧州市人民医院普外二科
- 折叠
摘要
Abstract
Objective To study the expressions of Bcl - 2, Bag - 1 in colon carcinoma and its relationship to clinical pathological characteristics and prognosis of colon cancer. Methods Immunohistochemistry was used to detect the expressions of Bcl -2, Bag - 1 proteins in 55 cases of colon cancer tissues, 33 para - cancer tissues and 15 normal colon tissues and analyze them integrated with clinical pathological features and prognoses. Results The positive rates of Bcl - 2 and Bag - 1 expressions were significantly higher in colon cancer tissues ( 80. 2％ , 72. 7％ ) than in para - cancer ( 60. 6％ , 48. 5％ ) and normal colon ( 0 ), the difference was significant ( P ＜ 0. 05 ). Bcl - 2 and Bag - 1 expressions were related to lymph node metastasis, tumor differentiation and clinical staging ( P ＜0. 05 ), but not to age , gender, tumor size, depth of invasion, carcinoemhryonic antigen ( CEA ), etc. Bcl - 2 and Bag - 1 expressions showed high consistency ( P ＜ 0. 01 ). The 5 - year and 10 - year cumulative survival rates of Bcl - 2 and Bag - 1 positive colon cancer patients were significantly lower than that of negative patients ( P ＜0. 05 ). Conclusion Bcl - 2 and Bag - 1 , closely related to the biological behaviors of colon cancer, can be used as predictive factors for prognoses of colon cancer patients.关键词
Bcl-2/Bag-1/结肠肿瘤/病理学,临床/累积生存率分类
医药卫生引用本文复制引用
兰涛,张金生,任俊华,苑建磊..Bcl-2和Bag-1在结肠癌组织中的表达及其意义[J].中国全科医学,2011,14(12):1314-1317,4.
