神经损伤与功能重建2011，Vol.6Issue(1)：24-27,4.DOI:10.3870/sjsscj.2011.01.006
普罗布考对高同型半胱氨酸血症致兔动脉粥样硬化的作用
Effects of Probucol on Atherosclerosis in Rabbits Induced by Hyperhomocysteinemia
吴乐 1黎红华 1武强 1王晓昆2
作者信息
- 1. 广州军区武汉总医院,神经内科,武汉,430070
- 2. 广州军区武汉总医院,医学实验中心,武汉,430070
- 折叠
摘要
Abstract
Objective: To observe the effect of Probucol on atherosclerosis in rabbits induced by hyperhomocysteinemia. Methods: Twenty-four male rabbits were randomly divided into three groups. The control group was fed on common food; the homocysterine (Hcy) model group was fed on high-methionine food with 1％ methionine; the treatment group was fed with high-methionine food and Probucol (lg/d perfused into stomach). Blood samples have been collected on week 20 after the diets and the serum lipids and plasma total Hcy (tHcy) were measured. Western-blotting was used to investigate the expression of nuclear factor-kB (NF-kB) in aorta. The pathological changes of the aorta were examined under light microscopy. Results: The lipids in the serum and the expression of NF-kB were significantly reduced in the treatment group relative to those in the Hey model group. Aortic changes were also attenuated in treatment group when compared to those in the Hey model group. Conclusion: Probucol could decrease serum lipids level and reverse the aortic atherosclerotic changes induced by Hey, probably by way of down-regulating NF-kB expression.关键词
普罗布考/同型半胱氨酸/动脉粥样硬化/核转录因子-κBKey words
probucol/ homocysterine/ atherosclerosis/ nuclear factor-kB分类
医药卫生引用本文复制引用
吴乐,黎红华,武强,王晓昆..普罗布考对高同型半胱氨酸血症致兔动脉粥样硬化的作用[J].神经损伤与功能重建,2011,6(1):24-27,4.
