安徽医科大学学报2011，Vol.46Issue(1)：49-52,4.
玉屏风多糖对小鼠化学性肝损伤的影响
Effects of polysaccharides from Yu-Ping-Feng powder on chemical liver injury in mice
摘要
Abstract
Objective To investigate the effects of polysaccharides from Yu-Ping-Feng powder(YPF-P) on chemical liver injury induced by D-Gal in mice. Methods The model of mice chemical liver injury was induced by D-Gal on day 7 after treatment with YPF-P. The levels of alanine aminotransferase ( ALT), aspartate aminotransferase (AST) in serum and the contents of malondiadehyde ( MDA ), glutathione ( GSH ) , superoxide dismutase ( SOD ) in liver homogenate were measured by using of spectrophotometers. Immunohistochemistry was used to detect the expression of TNF-α in hepatic tissue. Hepatic pathological examination was observed. Results YPF-P significantly decreased the serum transaminase levels, decreased MDA content and enhanced SOD and GSH levels in liver homogenate. YPF-P also inhibited the expression of TNF-α and reduced the pathological damage in liver. Conclusion YPF-P has protective effects on chemical liver injury in mice. It may associate with the enhancement of antioxidant ability.关键词
肝疾病/化学诱导/肿瘤坏死因子-α/脂质过氧化作用/药物作用Key words
liver diseases/chemically induced/tumor necrosis factor-alpha/lipid peroxidation/drug effects分类
医药卫生引用本文复制引用
陈方军,李俊,王佳佳..玉屏风多糖对小鼠化学性肝损伤的影响[J].安徽医科大学学报,2011,46(1):49-52,4.基金项目
安徽省自然科学基金资助(编号:050431001) （编号:050431001）
