摘要
Abstract
Objective To evaluate efficacy and safety of sufentanil and fentanyl in patient-controlled intravenous analgesia (PCIA) for postoperative thoracic surgery. Methods Eighty ASA Ⅰ or Ⅱ patients scheduled for thoracic surgery under general anesthesia were randomly and double-blindly allocated into four groups (n = 20 each): fentanyl 30 μg/kg in F1 group, fentanyl 40 μg/kg in F2 group, sufentanil 3 μg/kg in S1 group, sufentanil 4 μg/kg in S2 group. PCIA will start after patient awake extubation( each drug was diluted to 100 ml saline water, background dose 2 ml/h, bolus of 1 ml after a loading dose of fentanyl 0. 05 mg, locking time 15 min). Vital signs including MAP, HR, RR, SPO2 and side effects such as nausea, vomiting, breath depression and the scores of pain and sedation would be recorded at the time points of 1,4,8,12,24,48 h after operation. The cumulative sufentanil and fentanyl consumption would be recorded at 48 h. Results The scores of pain in group S2 were significantly lower and the scores of sedation were significantly higher than that of other three groups(P ＜ 0. 05 ) during postoperative 1-12 hours period. The consumption of analgesic drugs was comparable between four groups. The SPO2 in group S2 dropped significantly within 4-8 h after operation( P ＜0. 05 ). The side effects were similar in all groups. Conclusion Intravenous postoperative analgesia with equivalent dose of sufentanil has a better analgesic effect than fentanyl. The sedation effect is stronger and respiratory depression is less in patients receiving sufentanil than those receiving fentanyl.关键词
镇痛,病人控制/舒芬太尼/药理学/芬太尼/药理学/胸外科手术Key words
analgesia, patient-controlled/ sufentanil/pharmacology/ fentanyl/pharmacology/ thoracic surgical procedures分类
医药卫生
