中华医学杂志（英文版）2011，Vol.124Issue(6)：892-896,5.DOI:10.3760/cma.j.issn.0366-6999.2011.06.016
Prediction of contrast-induced nephropathy in diabetics undergoing elective percutaneous coronary intervention: role of the ratio of contrast medium volume to estimated glomerular filtration rate
Prediction of contrast-induced nephropathy in diabetics undergoing elective percutaneous coronary intervention: role of the ratio of contrast medium volume to estimated glomerular filtration rate
WANG Xue-chao 1JIANG Yun-fa 1FAN Wei-ze 1LI Shi-qiang 1FU Xiang-hua 1WANG Yan-bo 1JIA Xin-wei 1WU Wei-li 1GU Xin-shun 1ZHANG Jing 1SU Jian-ling 1HAO Guo-zhen1
作者信息
- 1. Department of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China
- 折叠
摘要
Abstract
Background Diabetic patients undergoing percutaneous coronary intervention (PCI) have a higher incidence of contrast-induced nephropathy (CIN) than nondiabetic patients, and no pharmacological approach has been demonstrated to offer consistent protection. Therefore, identifying individuals who are at increased risk becomes essential. This study was designed to assess the predictive role of the ratio of contrast medium volume to estimated glomerular filtration rate (CMV/eGFR) in diabetic patients undergoing elective PCI who developed ClN.Methods We retrospectively investigated clinical factors associated with the development of CIN in 114 diabetic patients who had undergone elective PCI. The risk factors for CIN included age, gender, body mass index (BMI), left ventricular ejection fraction (LVEF), hemoglobin (Hb), fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), volume of contrast medium, basic levels of serum creatinine (Scr), the number of treated vessels and the number of stents used.We conducted a stepwise regression analysis to evaluate the predictive role of these risk factors in the incidence of CIN.Results The incidence of CIN was 18.4％ (21/114). There were no significant differences in age, gender, BMI, LVEF, Hb,FPG, HbA1c, and incidence of hypertension and number of acute myocardial infarction (AMI) in patients between the CIN (n=21) and the non-CIN (n=93) groups. However, the eGFR was significantly lower ((72.0±12.5) ml·min-1·1.73 m-2 vs.(82.0±16.5)ml·min-1·1.7m-2, P=0.010), and the basic serum creatinine level ((1.07±0.12) mg/dl vs.(0.97±0.19) mg/dlP=0.014) was significantly higher in the CIN group. In addition, the volume of contrast medium was significantly larger
((253±75)ml vs. (211±71)ml, P=0.017) and the CMV/eGFR ratio was significantly greater (3.64±1.26 vs.2.70±1.11,
P=0.001) in the CIN group. Stepwise regression analysis showed that the CMV/eGFR ratio was a significant independent predictor for the development of CIN (P=0.001). At a cut-off point of ＞3.1, the CMV/eGFR ratio exhibited 71％ sensitivity
and 70％ specificity for detecting CIN.Conclusion The CMV/eGFR ratio could be a valuable predictor of CIN for diabetic patients after elective PCI. At a cut-off point of＞3.1, the CMV/eGFR ratio was an optimal predictor for the incidence of CIN.关键词
contrast-induced nephropathy/diabetes mellitus/contrast media/glomerular filtration rate/percutaneous coronary interventionKey words
contrast-induced nephropathy/diabetes mellitus/contrast media/glomerular filtration rate/percutaneous coronary intervention引用本文复制引用
WANG Xue-chao,JIANG Yun-fa,FAN Wei-ze,LI Shi-qiang ,FU Xiang-hua,WANG Yan-bo,JIA Xin-wei,WU Wei-li,GU Xin-shun,ZHANG Jing,SU Jian-ling,HAO Guo-zhen..Prediction of contrast-induced nephropathy in diabetics undergoing elective percutaneous coronary intervention: role of the ratio of contrast medium volume to estimated glomerular filtration rate[J].中华医学杂志（英文版）,2011,124(6):892-896,5.
