国际口腔医学杂志2011，Vol.38Issue(1)：98-101,4.DOI:10.3969/j.issn.1673-5749.2011.01.027
Oct4及其亚型调控细胞多能性的研究进展
Research progress on pluripotency regulation by Oct4 and its isoforms
摘要
Abstract
Reprogramming of somatic cells to embryonic stem cell (ESC)-like induced pluripotent stem cells has been achieved by transfection of the four transcriptions factors (oct4, sox2, c-Myc and klf4). Oct4 is indispensable for reprogramming, and plays important roles in transcriptional regulation, signal transduction, epigenetic modification and so on. By reviewing how Oct4 and its isoforms contribute to pluripotency maintenance in ESC, we show how Oct4 works in pluripotency regulation of cellular reprogramming. Meanwhile, this will help to provide rationale for the researches on stemneas regulation by Oct4 in dental pulp stem cell.关键词
Oct4/重编程/多能干细胞/牙髓干细胞Key words
Oct4/ reprogramming/ pluripotent stem cell/ dental pulp stem cell分类
生物科学引用本文复制引用
孔倩颖..Oct4及其亚型调控细胞多能性的研究进展[J].国际口腔医学杂志,2011,38(1):98-101,4.基金项目
国家自然科学基金资助项目(81070830) （81070830）
广东省自然科学基金资助项目(9151008901000199) （9151008901000199）
