重庆医学2011，Vol.40Issue(1)：1-2,6,封3,4.DOI:10.3969/j.issn.1671-8348.2011.01.001
胃乐散对急性化脓性梗阻性胆管炎大鼠肝脏的保护作用
Liver protection of wei-le-san in acute obstructive suppurative cholangitis rats
摘要
Abstract
Objective To observe the liver protection of wei-le-san in acute obstructive suppurative cholangitis. Methods The acute obstructive suppurative cholangitis model of wistar rat was prepared by incompletely ligating biliary tract. After wei-le-san were administrated 72 hours by intragastric administration,blood samples were collected for the level of bilirubin,hepatic function. histopathological examine. Histopathological changes of liver and bile duct tissues were observed through naked eye and light-microscope. Results The level of TBIL,AIT and AST all were increased in model group compared with sham operated group(P＜0.05, P＜0.01). The level TBII,ALT and AST in serum were decreased after treatment with wei-le-san 0.2 g/kg,but were higher than sham operated group (P＜0.05). Wei-le-san treatment could significantly reduce the histopathological damage, such as liver intumesce,hepatocyte necrosis and pus music were decreased compared with liver tissue of acute obstructive suppurative cholangitis rat. Conclusion Wei-Le-san can significantly protect liver function and tissue morphous in acute obstructive suppurative cholangitis rat.关键词
胆管炎/肝功能试验/胆红素/肝脏/胃乐散Key words
cholangitis/ liver function tests/ bilirubin/ liver/ wei-le-san引用本文复制引用
舒涛,范振海,吴芹,杨桂荷,余丽梅,兑丹华..胃乐散对急性化脓性梗阻性胆管炎大鼠肝脏的保护作用[J].重庆医学,2011,40(1):1-2,6,封3,4.基金项目
遵义市科技局资助课题[遵市科合社字2009(11)]. （11）
