中国免疫学杂志2011，Vol.27Issue(4)：330-334,5.DOI:10.3969/j.issn.1000-484X.2011.04.010
广州地区人类白细胞抗原-Ⅰ类与丙型肝炎病毒-6a型感染相关性的研究
Study on association between hepatitis C-6a and HLA-Ⅰ allele in Guangzhou area
摘要
Abstract
Objective :To study the association between hepatitis C-6a and HLA-Ⅰ allele in Guangzhou area .Methods :250 individuals of HCV antibodies positive and 621 health blood donors in Guangzhou area were enrolled in this study .Nested polymerase chain reaction (PCR ) was applied to detect HCV RNA in the sera .The gene sequences in E1 and NS5B area were detected for gene typing of HCV .LUMINEX SSO methods was used to detect the HLA-Ⅰ allele .The relative risk was evaluated in regular formular .Results :There were 69 samples as HCV-6a gene type in the 250 persons .RR value in A * 33 ,A * 30 was beyond 4 ,and RR value in B * 56 ,B * 54 ,B * 55 ,B * 58 ,B * 76 was also more than 4 .Conclusion :HLA-A19 and HLA-B22 are important genetic factor for infection of HCV-6a .关键词
HLA/HCV-6a/感染/相关性分类
医药卫生引用本文复制引用
夏文杰,叶欣,付涌水,王怡仲,许茹,徐秀章,陈扬凯,贝春花..广州地区人类白细胞抗原-Ⅰ类与丙型肝炎病毒-6a型感染相关性的研究[J].中国免疫学杂志,2011,27(4):330-334,5.基金项目
本文为广东省医学科学技术研究基金(No.A2010495)、广州市医药卫生研究基金(No.2009-YB-135)和医药卫生科技重点项目基金资助(No.2009-YB-135) （No.A2010495）
