四川医学2011，Vol.32Issue(1)：7-9,3.
IKCal蛋白产物在人宫颈鳞状上皮细胞癌组织及正常宫颈组织中表达差异分析
The expression of intermediate-conductance-Ca2+-activated K+ channels' protein in the tissues of cervical cancer
摘要
Abstract
Objective To compare the intermediate-conductance-Ca2+-activated K+channels (IKCal) protein in the tissues of cervical cancer with the normal tissue by the immuno-histochemical method. Methods The immuno-histochemical method was used to examine the IKCal protein in the 18 cases normal cervical tissue and 30 cases of different differentiation of cancer cells. Results ①All the specimens of cervical cancer were expressing the IKCal protein in the nucletis; there was only 1 case expressing the IKCal antibody. The expression rate of IKCal protein in cervical cancer was higher than in normal cervix (Z=-6. 109, P= 0. 00, P＜0.05). ②the expressions of IKCal protein in the cervical cancer were related in the degrees of differentiation of the cancer cells ( x2= 16. 468 ,P= 0. 00,P＜0. 017). Conclusion There are higher expressions of IKCal protein in the cervical cancer than in the normal cervix. The relationship between the degrees of differentiation of cervical cancer' cells and the expressions of IKCal protein is negative correlation. The over-expression of IKCal should be related with the occurrence and development of cervical cancer.关键词
钙激活性中电导钾离子通道/子宫颈鳞状上皮细胞癌/免疫组织化学分类
医药卫生引用本文复制引用
林海蕤,毛熙光,黄桂英,鲁照明..IKCal蛋白产物在人宫颈鳞状上皮细胞癌组织及正常宫颈组织中表达差异分析[J].四川医学,2011,32(1):7-9,3.基金项目
四川省科技厅项目(编号:2008 JY0014-1) （编号:2008 JY0014-1）
