山东医药2011，Vol.51Issue(1)：4-6,3.
角果木二萜Tagalsin的抗肿瘤作用
Anti-tumor effect of biterpenes tagalsin in ceriops tagal
摘要
Abstract
Objective To study the anti-tumor effect of biterpenes tagalsin of ceriops tagal collected from the South China Sea.Methods The subcutaneously transplanted solid rumor models with Lewis and hepatoma-22 and the ascitic tumor models with hepatoma-22 were established.All the models were divided randomly into 5 groups: 5, 10 and 20 mg/kg biterpenes tagalsin groups, saline and CTX ( 10 mg/kg), each of which was composed of 10 mice.The biterpenes tagalsin were given by intragnstric administration, the CTX by intraperitoneal injection for 7 days, same volume of saline was given to the control group.The mice were killed 24 hours after the last medication, the the tumor inhibition rate, indexes of organ, increase in life span, apoptosis rate were calculated.Results With the dosage of 5-20 mg/kg (biterpenes Tagalsin), the tumor inhibition rate in lewis model by 12.62％ - 43.69％, and by 24.49％-48.30％ in the hepatoma-22 model;slgnillcanlly prolonged the life span of mice in the ascitic tumor models with hepatoma-22; the thymus index increased and the hepatic index droped in both solid tumor models; the apoptosis rate of the two kind of tumor cell correlated positively with the dosage of cembrane-type diterpenes(P ＜ 0.05 or ＜ 0.01 ).Conclusions The biterpenes tagalsin has significant anti-tumor effect by inducing apoptosis of tumor cells.关键词
角果木,Tagalsin/二萜/抗肿瘤作用Key words
ceriops tagal/ tagalsin/ biterpenes/ anti-tumor effect分类
医药卫生引用本文复制引用
王秀美,姚如永,孙蓓,时艳艳,梁军,郭云良..角果木二萜Tagalsin的抗肿瘤作用[J].山东医药,2011,51(1):4-6,3.基金项目
国家高技术研究发展计划(863计划)项目(2006AA09Z446). （863计划）
