实用肝脏病杂志2011，Vol.14Issue(1)：37-39,3.DOI:10.3969/j.issn.1672-5069.2011.01.014
立体定向放射治疗原发性肝癌伴下腔静脉癌栓的疗效评价
Efficacy of stereotactic conformal therapy in the treatment of patients with hepatocellular carcinoma with tumor thrombus in inferior vena cava
季洪兵 1吕光明1
作者信息
- 1. 350025,福州市,南京军区福州总医院肿瘤放射治疗中心
- 折叠
摘要
Abstract
Objective To evaluate the effects of stereotactic conformal therapy (SCT)in the treatment of patients with hepatocellular carcinoma with tumor thrombus in inferior vena cava. Methods 66 hepatocellular carcinoma patients with tumor thrombus in inferior vena cava were reviewed and analyzed by Kaplan-Meier and Cox regression analysis. 36 patients with tumor thrombus in inferior vena cava with hepatocellular carcinoma were treated with stereotactic conformal therapy (body gamma knife),and 30 patients did not receive stereotactic conformal therapy, The planned target volume was encompassed by 50％ to 70％ isodose line,and tumor dose was 3Gy to 4Gy per fraction,with total dose ranging from 30Gy to 48Gy. Results In 36 patients with stereotactic conformal therapy,12(33.3％ )were in complete remission, 10(27.8％ )in partial remission ,13 ( 36.1％ )were in no change,and 1 (2.8％)showed disease progression. The remission rate of tumor thrombus in inferior vena cava was 61.1％ and one-year survival rate was 27.8％ with the median survival of 9.8 months. In the non-SCT-treated 30 patients,one-year survival rate was 11.5％ and the median survival was 3.5 months. Cox proportional hazards model analysis showed that the number of tumors and Child-Pugh class were the independent prognostic factor for the survival probability of the patients. Conclusion The stereotactic conformal radiotherapy is an effective method for treatment of tumor thrombus in inferior vena cava in patients with hepatocellular carcinoma.关键词
肝细胞癌/立体定向放射治疗/下腔静脉癌栓引用本文复制引用
季洪兵,吕光明..立体定向放射治疗原发性肝癌伴下腔静脉癌栓的疗效评价[J].实用肝脏病杂志,2011,14(1):37-39,3.
