实用肝脏病杂志2011，Vol.14Issue(1)：33-36,4.DOI:10.3969/j.issn.1672-5069.2011.01.012
肝细胞癌组织HSP70、p53和PCNA的表达及其意义
Expression of heat shock protein 70,p53 protein and proliferating cell nuclear antigen in hepatocellular carcinoma
谢本维 1蒋亚建 2杜翔 1曾晓华 1李世学 1次罗 1小平措 1蒋业贵3
作者信息
- 1. 850007,拉萨市,西藏军区总医院感染病科
- 2. 浙江大学竺可桢学院
- 3. 第三军医大学西南医院全军感染病研究所
- 折叠
摘要
Abstract
Objective To invetstigate the expression and significance of heat shock protein 70(HSP70),p53 and proliferating cell nuclear antigen (PCNA)in hepatocellular carcinoma (HCC).Methods HSP70,p53 and PCNA were determined in liver tissues of control,chronic hepatitis B,liver cirrhosis and HCC by immunohistochemistry.Resultes The positive rates of HSP70,p53 and PCNA in HCC were higher than that in non-tumor tissues (x21=27.16,x22=67.6,x23=40.6, P＜0.01 ); HSP70 expression increased progressively in liver tissues of control,chronic hepatitis B,liver cirrhosis and HCC;The positive rates of HSP70 and p53 in well-differenciated HCC were lower than that in poorly-differenciated HCC (x21=6.8,P1＜0.01,x22=6.1,P2＜0.05);the expression of PCNA were not associated with histological grades (x2=2.4,P＞0.05);The expression of HSP70 was closely correlated to that of p53 and PCNA in HCC (x21=41.3,x22=41.4,P＜0.01).Conclusion Expression of HSP70 is high in HCC.The expressions of HSP70,p53 and PCNA are closely correlated,which may play an important role in hepatocarcinogenesis.关键词
肝细胞癌/热休克蛋白/p53蛋白/增殖细胞核抗原/免疫组织化学引用本文复制引用
谢本维,蒋亚建,杜翔,曾晓华,李世学,次罗,小平措,蒋业贵..肝细胞癌组织HSP70、p53和PCNA的表达及其意义[J].实用肝脏病杂志,2011,14(1):33-36,4.
