医药导报2011，Vol.30Issue(1)：8-11,4.DOI:10.3870/yydb.2011.01.004
特非那定衍生物结构变化对肿瘤细胞Tca-8113凋亡的影响
The Effects of Terfenadine Derivatives with Different Structures on Apoptosis in Tca-8113 Cells
摘要
Abstract
Objective To investigate the effects of terfenadine derivatives with different structures on apoptosis in Tca-8113 cells. Methods Hoechst33258 stain and AO/EB stain were used to measure the apoptosis in Tca-8113 cells cultured with different compounds for 24 h. Results All four terfenadine derivatives ( n-propyl, allyl, bromideand vinyl) induced tumor cells apoptosis. The apoptosis rate measured by Hoechst33258 stain were (35.20±3.50)％ , (59.69±4.70)％ , (44.55± 4.20)％ and (56.32±5.10)％ , respectively. The apoptosis rate measured by AO/EB stain were(55. 14±9. 70)％ ,(88. 23± 11.80) ％ , ( 72.47 ±9. 30) ％ and (92.46± 13. 10) ％ , respectively. Conclusion All four different terfenadine derivatives promote apoptosis of Tca-8113 cells. The compounds with alkenyl structure have shown more significant pro-apoptosis effects, which may be related to an increase in the number of unsaturated bonds.关键词
特非那定/衍生物/人舌鳞癌Tca-8113细胞/细胞凋亡分类
医药卫生引用本文复制引用
陈琛,魏欣,汪道文..特非那定衍生物结构变化对肿瘤细胞Tca-8113凋亡的影响[J].医药导报,2011,30(1):8-11,4.基金项目
武汉市科技计划项目(基金编号:200960223070) （基金编号:200960223070）
