中国人兽共患病学报2011，Vol.27Issue(1)：14-18,5.
福建省肠道病毒71型分离株(2010FJLY008)全基因组核苷酸序列分析
Sequence analysis on complete genome of an enterovirus 71 strain (2010FJLY008) isolated in Fujian Province
摘要
Abstract
To investigate genetic background of current EV71 isolates in Fujian province and track possible mutations occurred in circulating EV71 strains, the complete genome of EV71 strain 2010FJLY008 was sequenced, which were isolated from specimens of an HFMD patient in Fujian in 2010, and the homology comparison and phylogenetic analysis were conducted. Sequence analysis revealed that the full-length of 2010FJLY008 strain was 7403bp, sharing the high homology with Fuyang17.08-2 both in nucleotide and amino acid sequences, with 98.2％ identity in nucleotides and 99.5％ in amino acids, respectively. The full-length VP1 region and genome-based phylogenetic analysis also indicated that strain 2010FJLY008 had the near genetic relationship with Fuyang17.08-2, in that both belonged to the same subgenotype, C4a. EV71 strain 2010FJLY008 had the close relationship with Fuyang17.08-2 in genomic structure, homology comparison of nucleotides and amino acids, the fulllength VP1 region and genome-based phylogenetic analysis, however, no obvious antigenic drift or mutations were observed.关键词
肠道病毒71型/全基因组/核苷酸序列分析分类
医药卫生引用本文复制引用
陈炜,严延生,周朝晖,沈晓娜,张拥军,谢剑锋,吴冰珊,王金章,翁育伟,郑奎城..福建省肠道病毒71型分离株(2010FJLY008)全基因组核苷酸序列分析[J].中国人兽共患病学报,2011,27(1):14-18,5.基金项目
艾滋病和病毒性肝炎等重大传染病防治科技重大专项-突发传染病病原体快速检测与现场机动采样技术平台研究(2009ZX10004-106)资助项目 （2009ZX10004-106）
