南京医科大学学报（自然科学版）2011，Vol.31Issue(1)：123-126,128,5.
儿童手足口病重症病例影响因素的病例对照研究
Case-control study on effect factors of serve Hand-foot-mouth disease among children
摘要
Abstract
Objective:To explore the effect factors of serve Hand-foot-mouth disease (HFMD)among children. Methods: A hospital-based case-control study was conducted on two groups of children matched by sex, age and hospital of time. Interview was carried out with uniform designed questionnaires between the case-group with serious complication and control-group with mild symptoms. Cox's proportional hazards regression analysis was then performed. The pathogen of HFMD was confirmed by RT-PCR. Results: Time intervals between onset date and admission date (OR=1.668,95％CI: 1.307-2.128),heating (OR=5.181,95％CI: 1.939-13.844) 、fever duration (OR= 1.562,95％CI: 1.142-2.13S), stiff neck (OR =3.188,95％CI: 1.055-9.634), the higher number of white blood cell (OR= 1.038,95％ CI: 1.013-1.064)and neutrophilic granulocyte (OR =1.235,95％ CI: 1.108-1.378) ,and Enterovirus71 infection (OR = 5.069,95％CI:2.472-10.393)were risk factors of HFMD among children with serious symptoms, However,lymph-cell counts increase (OR=0.968,95％CI:0.944-0.992),Children infected with CoxA16 (OR=O. 191,9S％CI:0.094-O.388)were the pretection factors. The risk factors were found with multivariate analysis,and were associated with time intervals between onset date and admission date(OR= 1.668,95％CI: 1.122-2.477),the higher number of white blood cell (OR=1.304,95％CI: 1.080-1.575)and neutrophilic granulocyte (OR=1.088,95％CI: 1.001-1.184),The protections factors was associated with CoxA16 infection (OR=0.169,9S％CI:0.038-0.753). Conclusion: To strengthen clinical surveillance and etiology surveillance of HFMD disease,early diagnosis and early treatment can effectively prevent children developing severe hand-foot-and-mouth disease possibility.关键词
手足口病/重症病例/肠道病毒71型/病例对照/影响因素Key words
hand-foot-mouth disease/ serve cases/ Enterovirus71/ case-control/ effect factors分类
医药卫生引用本文复制引用
汤奋扬,汪华,嵇红,李亮,祖荣强,许可,霍翔,吴斌,朱凤才,羊海涛..儿童手足口病重症病例影响因素的病例对照研究[J].南京医科大学学报（自然科学版）,2011,31(1):123-126,128,5.基金项目
国家科技支撑计划(2008BAI70B00) （2008BAI70B00）
